![Opioid use, opioid withdrawal, painkiller use, painkiller withdrawal, and drug misuse.](https://static.wixstatic.com/media/cad2a7_3fa45bfd376c4d409242c14bd5cb1504~mv2.jpeg/v1/fill/w_980,h_980,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/cad2a7_3fa45bfd376c4d409242c14bd5cb1504~mv2.jpeg)
3 or more of the following symptoms are observed after the cessation/ reduction in opioid use or administration of a opioid antagonist after a period of opioid use.
Dysphoric mood
Nausea
Muscle arches
Lacrimation
Pupillary dilation, piloerection, or sweating
Diarrhea
Yawning
Fever
Insomnia
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